Innovation Paradigm of Cell Therapy Models Driven by Organoid Technology
ZHANG Qianyue, YIN Xiaolei*
Cell therapy, as a revolutionary medical approach, holds significant potential in tissue regeneration and tumor treatment. However, its clinical translation is hampered by functional deficiencies in cells from traditional two-dimensional culture, inefficient transplant integration, and a lack of targeted therapies. Organoid tech nology, through its core mechanism of “three-dimensional microenvironment reconstruction-multicellular synergyself-organization”, is driving a paradigm shift in cell therapy from “passive replacement” to “active reconstruction”. This technology is advancing cell therapy from a laboratory concept toward standardized clinical treatment, providing crucial theoretical guidance and practical pathways for the industrial development of precision medicine and regenerative medicine. This review systematically elaborates on the molecular mechanisms through which organoid technology drives innovation in cell therapy, summarizes its prominent advantages in creating high-quality cell sources, enhancing transplantation-integration efficiency, and achieving personalized treatment, and discusses current challenges alongside novel explorations for future multidisciplinary development.
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