Home > Browse Issues > Vol.27 No.1
Growth Hormone Receptor and Signal Transduction
Ming-Zhe Zhang, Dan Ye, Zhi-He Zhang, Xi-Lian Hu, Ning Han, Mu-Yuan Zhu *
College of Life Sciences, Zhejiang University, Hangzhou 310012, China
Abstract: Growth hormone receptor (GHR) is a member of cytokine/hematopoietin receptor superfamily. The dimerization of two GHRs binding to growth hormone (GH) is the initiating step of signal transduction. It rapidly phosphorylates Janus kinase 2 (JAK2) to activate four different pathways into cells and elicit various physiological effects in vivo. This review introduces the structure characteristic and tissue distributions of GHR， and discusses GHR-media signal transduction.
CN
EN