Effect of Donor Factors on Drug Heterogeneity of Human Umbilical Cord Mesenchymal Stem Cells
WU Yan, LIU Yingying, JIANG Shu, ZHANG Yun, ZHAO Chuanxin, XIE Liang, ZHOU Peihua, JIANG Yingchun*
hUC-MSCs (human umbilical cord mesenchymal stem cells), characterized by their ease of isolation and expansion, significant differentiation potential, robust proliferative capacity, scalability in production, and low immunogenicity, hold great promise as one of the most clinically promising stem cell drugs. As the application for marketing authorization of hUC-MSC-based drugs is being put on the agenda, the inconsistency in quality and clinical efficacy due to donor variability has emerged as one of the major constraints for drug commercialization. Therefore, this article provides a comprehensive summary of the impact of various donor factors, including age, gestational age, fetal weight, gender, obesity, mode of delivery, on hUC-MSCs. It also explores potential solutions to address these issues. By doing so, the study aims to offer insights into achieving consistent therapeutic efficacy of hUC-MSC-based drugs and clearing obstacles for product commercialization, ultimately paving the way for the widespread application of these promising stem cell therapies.
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