Research Progress on the Interaction between Extracellular Acidic Microenvironment and Hypoxia in Regulating Tumor Cells
ZHANG Zhihui, AN Caiyan*
The extracellular acidic microenvironment is one of the important characteristics of the tumor microenvironment, which is mainly caused by metabolic reprogramming of tumor cells. The extracellular acidic microenvironment exists in various tumors, and its impact on the occurrence, development, and treatment of tumor cells has become a major focus of research in recent years. The extracellular acidic microenvironment can promote tumor cell proliferation, invasion, angiogenesis, immune suppression, and drug resistance. It is crucial to develop new therapeutic methods specifically targeting the extracellular acidic microenvironment. This study proposes a novel therapeutic strategy for treating tumors by targeting lactate metabolism to inhibit lactate formation, regulating the balance of extracellular acidic microenvironment pH, and designing pH sensitive chemical bonds and hypoxia sensitive nanomaterials.
CN
EN