Advances in Spermatogonial Stem Cell Fate Regulation

SSCs (spermatogonial stem cells) are the unique adult stem cells because the balance between their self-renewal and differentiation determines lifelong spermatogenesis in the body, which also supports the transmission of genetic information from generation to generation in species. Over the past half century, the development of cell identification, culture, allogeneic transplantation and the study of fate regulation on SSCs have greatly improved our understanding of their biological properties. This review introduces the history, milestones, recent progress and unresolved issues still faced of SSC studies, and aims to summarize the current knowledge with a view to providing reference for fertility preservation, stem cell genetic modification, endangered species conservation, and livestock production