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Ribosomal Regulation of Protein Translation and Its Research Progress on Spermatogenesis


XIAO Huijuan, LI Huiling, GUO Xuejiang*, SHA Jiahao*

(State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China)
Abstract:

The process of protein synthesis is an essential step in gene expression, converting the genetic information encoded in mRNA (messenger RNA) into specific proteins. This process is highly conserved in various organisms and serves as the foundation for cell growth, development, reproduction, and adaptation to environmental changes. As the “executor” of protein synthesis, the ribosome plays an indispensable role in this complex and precise process. The synthesis of proteins and their precise regulation during spermatogenesis are crucial for normal sperm development. The intricacy of this regulation allows sperm to undergo morphological and functional changes during development, ultimately maturing into sperm capable of fulfilling fertilization tasks. This paper will delve into the composition and functions of the ribosome, as well as its regulatory mechanisms in the translation process, including its role in translation regulation during spermatogenesis, elucidating its significance in the field of reproductive biology