Advances in Transcriptional Regulation of Spermatogenesis

BU Zhiwen¹, LU Luyang¹, BAI Shun², KANG Zhenlong¹, HAN Shenglin¹*, YE Lan¹*

（¹State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China; ²Reproductive Center, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China)

Abstract:

Transcriptional regulation during spermatogenesis is a complex process. It consists of a series of gene expression and regulatory events that affect sperm formation, quality and function. Transcriptional regulatory mediates the expression of genes including sperm-specific genes, histone genes, and other regulatory factors. The expression and silencing of these genes are regulated by a variety of mechanisms, which includes transcription factors, epigenetic modifications, and non-coding RNA. Furthermore, transcriptional regulation plays different roles in different stages of spermatogenesis, including self-renewal and differentiation of spermatogonia stem cells, meiosis of spermatocytes, and metamorphosis and maturation of sperm cells. Thorough comprehension of transcriptional regulatory mechanisms in spermatogenesis is of great significance for studying the biological processes of spermatogenesis, resolving the pathological mechanisms of fertility disorders, and developing treatments for fertility problems.