The Abnormal Innate and Acquired Immunity in the Pathogenesisof Alzheimer’s Disease

AD (Alzheimer’s disease) is the most common neurodegenerative disease. The pathologicalhallmarks of AD include the extracellular deposition of Aβ (amyloid-β) and the intracellular NFTs (neurofibrillarytangles) composed of hyperphosphorylated tau in the brain. Although the underlying mechanisms of AD remain tobe fully elucidated, increasing evidence suggests that dysregulation of the immune system is closely associated withthe pathogenesis of AD. This paper reviews the recent progresses regarding the abnormalities of both innate and acquired immunity associated with AD. Hopefully, this review will provide new insights into the mechanisms underlying AD and offer a framework serving as a roadmap for future studies.