Identification of LDLR as an Entry Receptor of CCHFV

CCHFV (Crimean-Congo hemorrhagic fever virus), a member of the Orthonairovirus genus inthe Nairoviridae family of the Bunyavirales order, is a tick-borne RNA virus that causes severe hemorrhagic disease in humans, with fatality rate around 30%. It has been shortlisted as a priority pathogen according to the WHOR&D Blueprint. So far, there is no effective antivirals or vaccines for CCHFV infection. For more than 60 years since the discovery of CCHFV, the cellular entry receptor(s) have not yet been identified. In this study, WANG andcolleagues have identified LDLR (low density lipoprotein receptor) as an entry receptor for CCHFV. This study willnot only shed light on the mechanism of CCHFV infection, but also provide antiviral targets and potential therapeutic strategies against CCHFV.