Regulatory Mechanism between Mutant p53 and Mevalonate Pathway

The development of tumors is usually accompanied by the reprogramming of tumor cell metabolism to meet its adaptation to the tumor microenvironment and energy acquisition. Abnormal lipid metabolism has become one of the signs of metabolic changes in tumors. The MVA (mevalonate pathway), as an important cholesterol biosynthetic pathway in lipid metabolism, is active in tumor cells. The metabolic recombination function of mutp53 (mutant p53) in tumor cells is closely related to the active state of the MVA pathway. mutp53 can abnormally activate the MVA pathway through the sterol transcription factor SREBP2 (sterol response element binding protein 2) and further stabilize its own expression, and their interaction promotes the abnormal proliferation of tumor cells. This paper reviews the latest research progresses of the mutual regulation mechanism between mutp53 and MVA pathway, and provides new ideas for the cancer therapy targeting mutp53 and MVA pathway.