Myocardial Regeneration in Neonatal Mice: Models and Mechanisms

It used to be believed that the injured myocardium of mammalian could only be repaired by scar repair, which would not achieve tissue regeneration, and eventually induce heart failure. In recent years, a large number of reports have pointed out that mammals have the ability of cardiac regeneration based on the proliferation of cardiac myocytes in the early stage of life, which is strong enough to repair the damaged cardiac tissue and restore the normal function of the heart. However, this ability will be rapidly lost in the early postnatal period. The discoveries of myocardial regeneration in neonatal mice provide ideal animal models for exploring the molecular mechanisms of myocardial regeneration, and then contribute to the development of intervention targets for myocardial regeneration and repair. At present, the widely used neonatal mice models of myocardial injury and regeneration include apical resection model, myocardial infarction model, cryoinjury model, and so on. In this paper, the different methods to construct the regeneration models of neonatal mice after myocardial injury are summarized, so as the research progress of myocardial regeneration mechanisms by using neonatal mice myocardial regeneration models.