Studies on Protein Function of Cyclin-Dependent Kinase 2 and Its Inhibitors

ZHENG Nan^1,2,3, XU Yang^1,2,3*

(¹College of Life Science, Liaoning Normal University, Dalian 116081, China; ²Lamprey Research Center, Liaoning Normal University, Dalian 116081, China; ³Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China)

Abstract:

CDK2 (cyclin-dependent kinase 2) is one of the most important members of the CDK family. The abnormal expression or function of CDK is closely related to the pathogenesis of various diseases, such as tumors, viral replication and infection, immunodeficiency diseases, and male sterility. CDK2 inhibitors have been become a very attractive target in the research of anti-tumor drugs. Here, this artical reviewed the mechanisms of CDK2 in cell cycle regulation, cell proliferation, cell differentiation and cell apoptosis, as well as the development of CDK2 inhibitors.