Expression Characteristics and Functional Significance of Circular RNA in Triple Negative Breast Cancer

Circular RNA is a covalently closed circular molecule formed by reverse splicing of precursor RNA. In the past, circular RNA was considered as the “noise” of DNA transcription and did not participate in biological metabolic processes. However, recent studies have shown that abnormal expression of circular RNA can affect the occurrence and development of various malignant tumors, including triple-negative breast cancer. This article reviews the molecular mechanism of circular RNA in tumors and its functions in cell proliferation, apoptosis, migration, invasion, and drug resistance of triple-negative breast cancer.