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Comparison and Application of Cell Imaging Technology of Mesenchymal Stem Cells


LING Haiqian, XIE Peigen*

(Department of Spinal Surgery, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510600, China)
Abstract:

Mesenchymal stem cells are a class of cells with strong proliferative capacity, multidirectional differentiation potential and immunomodulatory ability. Studies have shown that stem cell transplantation may treat a variety of refractory diseases, such as Parkinson’s disease, spinal cord injury and tumors. However, the survival, distribution, proliferation, differentiation, immune rejection response and tumorigenicity of transplanted cells in the host are still unknown, so it is difficult to obtain exact and strong scientific evidence of disease progression and outcome after cell transplantation. Cell imaging technology (including radionuclide imaging, ultrasound imaging, magnetic resonance imaging and optical imaging) can realize real-time and non-invasive tracing of mesenchymal stem cells, so it has great application potential in the field of cell transplantation therapy and cell tissue regeneration medicine based on the research of mesenchymal stem cells. This paper focuses on the basic characteristics of mesenchymal stem cell imaging and its latest applications in medical research in order to provide more powerful support for further research on stem cell transplantation.