Role of DNA Methylation Regulated miRNA in Carcinogenesis of Lung Cancer

Lung cancer is the cancer with highest incidence/mortality rate in the world. The treatment process is beset by low cure rate and high metastasis rate. It is urgent to understand the molecular mechanism of lung cancer in the course of occurrence and development in order to find a better treatment plan. As small non coding RNA, miRNA can lead to mRNA degradation or translation inhibition of target genes. miRNA is regulated by epigenetic regulation, including DNA methylation, involved in a variety of cell processes, including cell differentiation, proliferation and apoptosis, and regulating disease status including cancer. DNA methylation is a reversible epigenetic regulation process. Currently, DNA demethylation drugs have been used in the clinical treatment of cancer, but it is still necessary to look for drugs with high specificity. In this paper, the role of DNA methylation regulated miRNA in the occurrence and development of lung cancer, as well as the research on the sensitivity of lung cancer to chemotherapy and radiotherapy are reviewed.