Research Progress of Musculin in Regulating Immunocytes

LIU Yijia^1,2, YU Jing¹*, LIU Ke^1,2, LI Suiyan², GAO Wenda³, YAN Jun¹*

(¹State Key Laboratory of Trauma, Burns and Combined Injury, Department of Special War Wound, Institute of Surgery Research, Army Medical University, Chongqing 400042, China; ²School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; ³Antagen Institute for Biomedical Research, Boston 02118, USA)

Abstract:

Musculin, a new transcription suppressor of basic helix-loop-helix structure, is not only involved in the generation, tissue development and differentiation of mammalian skeletal muscle, but also regulates the differentiation and function of T lymphocytes, B lymphocytes and innate lymphoid cells, indicating that this factor has a certain relationship with immune cells and may be used as a key regulatory factor for immune cells involved in immune diseases. Therefore, this paper summarized the recent research progress of Musculin in regulating immunocytes.