Research Progress of m6A Methylation Regulating Osteosarcoma

 Osteosarcoma is a common malignant bone tumor. The problems of high recurrence, high metastasis rate and chemotherapy resistance make the treatment of osteosarcoma more difficult. m6A methylation is the most common RNA modification in mammals, regulating the post-transcriptional expression of genes without changing the base sequence. It mainly participates in many biological processes and diseases through the three types of proteins: methyltransferase, methylated reading protein, and demethylase. It has been confirmed that m6A methylation of multiple genes is closely related to the occurrence and development of osteosarcoma. Therefore, this article reviews the researches on the relationship between m6A methylation and osteosarcoma, and aims to provide a new direction for the potential targeted therapy of osteosarcoma.