The Roles of Alternative Splicing in Gastric Cancer

Alternative splicing is the process by which mRNA splices in different ways to produce different mRNA splicing isomers. The final protein products will show different or antagonistic functional and structural characteristics. A large number of studies have revealed that splicing factor mutations are closely related to the occurrence and development of various human cancers. Through the study of different RNA splicing patterns and splicing regulation, a large number of candidate biomarkers and potential targets have been provided for tumor treatment. The latest mRNA sequencing technology can detect that about 95% of human genes have alternative splicing with multiple exons, and abnormal alternative splicing may lead to tumorigenesis. Although the study of alternative splicing in cancer is in full swing, there are few studies on the occurrence and development of gastric cancer. This article reviews the research progress of alternative splicing in gastric cancer.