Research Progress on the Involvement of HIF-1α in the Regulation of Bone Metabolism by MicroRNAs

LI Tingting¹, ZHANG Shihua¹, YUAN Yu², ZOU Jun¹*

(¹School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China; ²School of Physical Education and Sports Science, South China Normal University, Guangzhou 510631, China)

Abstract:

Bone is a kind of tissue with continuous metabolic renewal ability. The balance of bone metabolism is important for maintaining blood calcium homeostasis, repairing fractures, and changing bone structure to better adapt to load. Studies have shown that microRNAs are widely involved in the regulation of bone formation and bone resorption. In recent years, bone metabolism has been gradually involved in the researches which focus on HIF-1α (hypoxia inducible factor-1α). At present, some relevant cell experiments and animal experiments have explored part of the regulatory mechanisms, while the complete regulatory network remains to be studied. This study mainly reviews the research progress of HIF-1α involved in the regulation of bone metabolism by microRNAs, and aims to provide a theoretical basis for the diagnosis and prevention of bone metabolic diseases.