Research Progress on the Relationship between the Transmembrane-4-L6 Family 1 and Hepatocellular Carcinoma

ZHANG Huiwen¹, LI Cheng², LI Jiake¹, LI Jun¹, QIU Fu¹*

(¹Department of General Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China; ²Department of Radiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China)

Abstract:

HCC (hepatocellular carcinoma) is a malignant tumor with an extremely high mortality rate in the world, but the clinical treatment effect of HCC so far is not satisfactory. Therefore, it is urgent to find more reliable and safe treatment methods. TM4SF1 (transmembrane-4-L6 family 1) is one of the important members of the TM4SF, which mediates the signal transduction process that regulates cell development, activation, growth and movement. TM4SF1 plays important roles in the occurrence and development of HCC, lung cancer, colorectal cancer, bladder cancer, ovarian cancer, pancreatic cancer and other tumors. This article outlines the structure and function of TM4SF1, summarizes the mechanisms of TM4SF1 to promote the occurrence and development of HCC, and reviews the recent clinical application of TM4SF1 as an ideal antigen for cancer immunotherapy and new biomarker.