Expression and Significance of MMP-9 and VEGFR2 in Patients with Internal Hemorrhoids

This study aimed to study the expression and significance of MMP-9 (matrix metalloproteinase-9) and VEGFR2 (vascular endothelial growth factor receptor 2) in the tissues of patients with internal hemorrhoids. From December 2018 to December 2019, 110 internal hemorrhoids tissue sections, 59 males and 51 females, which were preserved in the pathology department of our hospital, were selected as the normal group. Another 110 relatively normal anal pad tissue sections preserved in the pathology department of our hospital at the same time were selected as the normal group (there was no history of hemorrhoids, but the anal pad specimens of patients who underwent surgical resection for low rectal cancer were used as the relatively normal anal pad group). Among them, 25, 29, 28, 28 cases were seperately in stage I, stage II, stage III, stage IV; 35, 45, 30 cases were seperately mild, moderate and severe. The expressions of MMP-9 and VEGFR2 were detected. The results showed that compared with the normal anal cushion tissue, the expressions of MMP-9 and VEGFR2 in internal hemorrhoids increased (P<0.05). Compared with stage I, III and III, the expression levels of MMP-9 and VEGFR2 in stage IV increased (P<0.05). There was no significant difference in the expression levels of MMP-9 and VEGFR2 between patients over 61 years old and patients under 75 years old (P>0.05). There was no significant difference in the expression levels of MMP-9 and VEGFR2 between male patients and female patients (P>0.05). Compared with patients with course less than three years, the expression levels of MMP-9 and VEGFR2 increased in patients with course more than three years (P<0.05). Compared with mild, the expression levels of moderate and severe MMP-9 and VEGFR2 increased (P<0.05), while those of severe MMP-9 and VEGFR2 increased (P<0.05). In short, MMP-9 and VEGFR2 were highly expressed in patients with internal hemorrhoids. The expression levels of MMP-9 and VEGFR2 in patients in stage II were higher than those in patients in stage I. The level was related with the severity, course of disease and the degree of interstitial edema, and participated in the development of internal hemorrhoids.