Application of Adipose Tissue Derivatives in the Field of Repair and Regeneration

LIU Yanjun¹, ZHOU Shuangbai¹, TANG Yan², TANG Qiqun², LI Qingfeng¹*

(¹Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; ²Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China)

Abstract:

Adipose tissue can be easily obtained in large quantities and has shown promise in the repairation of soft-tissue defects. Except of adipocytes, adipose tissue provides an abundant source of SVF (stromal vascular fraction) cells including stem cells, immune cells and blood-vessel related cells. These SVF cells secrete various cytokines and mediate immune regulation and injury repair, providing novel ideas for cell therapy and repair and reconstruction. However, it’s controversial to be widely used, due to the complex composition of adipose tissue, unclear quality evaluation criteria, and unstable efficacy. This review summarizes the preclinical and clinical studies of adipose tissue derivatives in the field of plastic repair to provide some guidance for the clinical application of adipose tissue derivatives.