The Prospect of Trop2-Targeting Drugs in Tumor Therapy

Trop2 is also called tumor-associated calcium signal transducer 2. It is a type of cell surface glycoprotein that is lowly or not expressed in normal tissues, but is highly expressed in a variety of tumors, such as pancreatic cancer, colon cancer and breast cancer. Trop2 plays an important role in the self-renewal, proliferation, invasion and transformation of tumor cells, and it is a molecular marker for clinical detection of tumor malignancy and a potential target for tumor therapy. This paper reviews the structure, physiological function, relationship between Trop2 and tumors, and its related drug development.