Research Progress of Charged Multivesicular Body Protein 5

CHMP5 (charged multivesicular body protein 5), whose homologue in yeast is Vps60 (vacuolar protein sorting-associated protein 60), is one of the highly conserved proteins. As an indispensable member of ESCRT III (endosomal sorting complex required for transport III), CHMP5 participates in many intracellular processes, such as protein degradation, signal transduction, and virus budding. CHMP5 is an antiapoptotic gene, which plays an important role in the formation of skeletal deformity and tumors such as acute myeloid leukemia. In addition, recent studies have shown that CHMP5 also functions in T cell differentiation, cell division, etc.