The Interaction between Mutp53 and NF-κB in Tumor Development

p53 is an important tumor suppressor. However, over 50% cancer bears mutp53 (mutant p53) leading to loss of function. As a key factor in the regulation of inflammatory response, nuclear transcription fac-tor NF-κB not only participates in immune response, but also drives the inflammation-associated carcinogenesis in cells. In addition, mutp53 and abnormal activation of NF-κB are closely related to poor prognosis and chemother-apy tolerance in cancer patients. There exists a mutational regulatory relationship between mutp53 and NF-κB in inflammation and tumor development. Therefore, mutp53 and NF-κB can act as potential targets for cancer therapy. This paper summarizes the underlying molecular mechanism for the interaction between mutp53 and NF-κB pro-teins in inflammation and tumor, the effect of the interaction during tumor progression, providing some cues for the further investigation of their interaction and design of new strategies for tumor treatment.