Multidrug Resistance-Associated Protein 1 and Its Correlation to Pathogenic Infections and Drug Resistances

 MRP1 (multidrug resistance-associated protein 1) is a member of the ABCC subfamily of the ATP-binding box transporter protein superfamily. It is widely distributed in the human body with a large number of transport substrates, and has important physiological, pathological and pharmacological functions. In addition to the close correlation with tumor and anti-tumor drug resistance, inflammatory and immune diseases, cardiovascular diseases, and neurological diseases, the role of MRP1 in infectious diseases has been increasingly concerned in recent years. This review will summarize the research progresses in the structure, function and regulation of MRP1 and its correlation with pathogenic infection and drug resistance.