Vol.30 No.3 (2008 June): 307-311

The Association of Annexin A2 with Malignant Tumor

Ai-Ran Zhang, Ning Pan, Ying-Chun Hou*

(College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China)

Abstract Annexin A2 (ANXA2) is a calcium-dependent phospholipid-binding protein. It is widely distributed in cell nucleus, cytoplasm as well as extracellular matrix and expressed mainly in human endothelial cells, mononuclear cells, macrophages, marrow cells and some tumor cells. As an important member of annexin family, it is associated with a series of vital biological activities including membrane formation, membrane transportation, exocytosis, endocytosis, cell proliferation, signal transduction, cell differentiation and apoptosis. Recently, study data showed that its expression level is notably changeable in tumor tissues and closely related to oncogenesis, cancer development, invasion and metastasis. The paper reviewed the new advances in the study on the relationship between ANXA2 and tumor.

Key words annexin A2; tumor; oncogenesis; invasion and metastasis

Received: January 4, 2008 Accepted: February 27, 2008
*Corresponding author. Tel: 86-29-85310274, Fax: 86-29-85310546, E-mail: ychhou@snnu.edu.cn