Roles of Jagged1 in the Immuno-tolerance Induced by Dendritic Cells

Zhen-Ping Teng, Fei-Yue Xing*, Zhe Yu, Yao-Ying Zeng
(Institute for Tissue Transplantation and Immunology, Key Laboratory of Minister of Education,Jinan University, Guangzhou 510632, China)

Abstract Jagged1 is one of ligands from Notch receptors in vertebrates. Recently, many researches indicate that it may induce maturation of dendritic cells, and that it may promote T lymphocytes to deviate to regulatory T cells or T-helper 2 cells, which results in the immuno-tolerance.

Key words Jagged1; dendritic cell; immuno-tolerance

Received: October 8, 2005 Accepted: April 7, 2006
This work was supported by the National Natural Science Foundation of China (No.30471635), the Natural Science Foundation of Guangdong Province (No.04010451, No.5006033), the Foundation of Talent Program of Jinan University (No.51204058)
*Corresponding author. Tel: 86-20-33010358, E-mail: fyxlj@hotmail.com