Vol.28 No.3（2006 June）：429-433
Progress in Rab5a
Abstract Rab5a is one of the members of Rab protein family, which belongs to small GTPases. Rab5a protein is an important rate-limiting component on early endocytic pathways. Recent researches have been strongly supported that Rab5a mainly regulated the fusion of early endosome and controlled the formation of vesicles on the plasma membrane and the downstream delivery of internalized molecules to a number of cellular locations. In this review, the advances on structure, interaction proteins and functions of Rab5a protein are introduced. Key words Rab5a; small GTPases; early endosome; endocysis
Received: October 24, 2005 Accepted: February 17, 2006 This work was supported by the National Natural Science Foundation of China (No.39970396), the Foundation for the Returned Overseas Scholars of Heilongjiang (No.LC04C02), the Scientific Research (Cooperation) Project for the Returned Overseas Chinese Scholars, the Heilongjiang Department of Education (No.1054HZ013) *Corresponding author. Tel: 86-451-86402052, E-mail: liyugene@hit.edu.cn |