Vol.28 No.3（2006 June）：405-409

Structure and Biology Function of T-STAR
Bing Chen^*, Lian Guo, Ling Zhang, Feng-Tian He¹
(Endocrinology Department of Southwest Hospital, ¹ Biochemistry Institute,Third Military Medical University, Chongqing 400038, China)

Abstract The gene of T-STAR is located in chromosome 8q24.2. Its expression product is about 55 kDa Sam68 analog—a new member of STAR family. T-STAR is an RNA-binding protein that has an RNA-binding domains and function region of tyrosine phosphorylation. T-STAR has been shown to be involved in spermatogenesis, regulation of cell proliferation or immortalization of transform cell by the pathways including tyrosine kinase signal transduction and pre-mRNA alternative splicing or activation of RNA. It is also thought to be related with some diseases.

Key words signal transduction; RNA-binding protein; alternative splicing; spermatogenesis

Received: October 08, 2005 Accepted: February 16, 2006

This work was supported by the National Natural Science Foundation of China (No.30271442, No.39980010)

^*Corresponding author. Tel/Fax: 86-23-68754138, E-mail: cb@mail.tmmu.com.cn