Vol.28 No.3（2006 June）：382-386

Function of PPAR-g and Related Signaling Pathways
Yong-Xi Chen, Wei-Ming Wang, Tong Zhou, Nan Chen*
(Department of Nephrology, Ruijing Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200032)

Abstract Peroxisome proliferater-activated receptor (PPAR) is among nuclear transcription factors superfamily and is activated by ligand. PPAR has three subtypes which are PPAR-a, PPAR-b/d and PPAR-g. Among these subtypes, PPAR-g has been thoroughly studied. PPAR-g inhibits inflammation by blocking JAK-STAT, activator protein-1 (AP-1), NF-kB, nuclear factor of activated T cells (NFAT) signaling pathways. It ameliorates sclerosis by inhibiting foam cell differentiating, inflammation and cell proliferation. It maintains glucose homeostasis by PI3K, leptin, adiponectin signaling pathway. It inhibits tumor cells growth by mediating cell cycles. Also, it is closely related to obesity by participating in adipocytes differentiation. Thorough understanding of those signaling pathways and interaction of relevant cytokines might help us while treating relevant diseases.

Key words PPAR-g; signaling pathway; mechanism; disease

Received: November 21, 2005 Accepted: January 16, 2006

This work was supported by the National Natural Science Foundation of China (No.30270613), Key Foundation of Shanghai Health Bureau (No.02III001), Key Subject of Shanghai (No.T0201), Key Subject of Shanghai Health Bureau (No.2003ZD002)

*Corresponding author. Tel: 86-21-64370045, E-mail: chen-nan@medmail.com.cn