Structure and Functions of CIN85

Fang Huang^*, Min-Juan Bian

(State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai 200032, China)

Abstract：CIN85 and CD2AP comprise a new family of adaptor proteins that plays important roles in animal development and diseases. They share a high sequence similarity in several functional domains that exhibit unique scaffolding function. Recent data suggest that the scaffolding function of CIN85 may control multiple cellular functions, such as down-regulation of receptor tyrosine kinases (RTK), regulation of apoptosis, and modulation of cell adhesion.

Key words:：CIN85; SH3 domain; proline-rich region; associated proteins

*Corresponding author. Tel: 86-21-54237296, Fax: 86-21-64174579, E-mail: huangf@shmu.edu.cn