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Spindle Assembly Checkpoint
Sai-Ying Ou, Gao-Liang Ouyang*, Shi-Deng Bao
(The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering,
School of Life Sciences, Xiamen University, Xiamen 361005, China)
Abstract： Chromosomes aligned to the metaphase plate and segregated to the mitotic spindle are regulated by the spindle assembly checkpoint. This surveillance mechanism monitors kinetochore-microtubule attachment and the integrity of the mitotic apparatus, and is able to delay the metaphase-anaphase transition until all chromosomes are properly aligned at the metaphase plate and established a bipolar orientation, ensuring equal segregation of genomic material among daughter cells. Functional defects in spindle assembly checkpoint can generate gross aneuploidy and are associated with tumorigenesis. In this review, we will focus on the molecular components of spindle assembly checkpoint pathway and the relationship between the function defects of this checkpoint and tumorigenesis.
Key words： cell cycle checkpoint; spindle assembly checkpoint; kinetochore; tumor
*Corresponding author. Tel: 86-592-2186091, Fax: 86-592-2188101, E-mail: oygldz@yahoo.com.cn
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