The Structure and Function of Protein Interacting with C a Kinase
Hong Xiao, Jing-Ming Yuan, Ya-Wei Shi*
(Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan, 030006, China)
Abstract： Protein interacting with C a kinase (PICK1) contains a single PDZ domain known to mediate the interaction with several receptors, transporters, ion channels and kinases, and a BAR domain interacted with other proteins and membrane besides PDZ domain itself, as well as a coiled-coil and an acidic amino acid regions. PICK1, as an adaptor protein between protein kinase C a (PKCa) and receptors at synapse performs its biological function through the interaction with different partners in synaptic plasticity, neurotransmitter regulation, peripheral nervous sensory, cell-cell adhesion and cell growth. In this review, we focus on the structure and function of PICK1.
Key words： PICK1; PDZ domain; BAR domain; function; structure
*Corresponding author. Tel: 86-351-7017661, Fax: 86-351-7018268, E-mail: yaweishi@sxu.edu.cn
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