Vol.26 No.2（2004 April）：93-97

Research Advances on Function of PLC-γ

ZHANG Bing^{1, 2}, WU Qiao^1*

（¹Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen university; ² Medical School, Xiamen University; Xiamen 361005, China）

Abstract: Phospholipase C-γ is rapidly activated in response to the activation of more than 100 different cell surface receptors by two different mechanisms, and catalyzes the hydrolysis of phosphatidylinositol 4, 5-bisphoaphate to inositol 1, 4, 5-trisphosphate and diacylglycerol. They mediate intracellular Ca²⁺ release and the activation of protein kinase C(PKC), respectively. This bifurcating pathway constitutes the cornerstone of a transmembrane signal transduction mechanism that is now know to regulate cell cycle, cell transformation, development, apoptosis of cell, and control actin cytoskeleton. Phospholipase C-γ has a wide crosstalk with the other pathways, for example, PKC, Ras, Ca²⁺ pathway et al.. Then, Phospholipase C-γ plays a important role in the metabolize of cell.

Key words: PLC-γ; signal transduction

*Corresponding author, E-mail: xgwu@xmu.edu.cn