Vol.26 No.6（2004 December）：567-570

The Cytoskeleton and Its Signal Regulation in Smooth Muscle Cells

Yun-Hui Cheng, Mei Han*, Jin-Kun Wen

（Hebei Laboratory of Medical Biotechnology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China）

Abstract: The cytoskeleton of smooth muscle cells (SMC) is a complex and dynamic network, which is an essential cellular structure for cell survive. Rho-associated coiled-coil kinase (ROCK) and Dial, as the downstream targets of Rho, induce the formation of the stress fibres. Protein kinase C plays a key role during the reorganization of cytoskeleton by different isoforms on subcellular location. The Rho and PKC develop cross-talk through Src signal pathway, regulating the cytoskeleton of SMC.

Key words: cytoskeleton; smooth muscle cell;Rho-like small GTPase; protein kinase C

*Corresponding author. Tel: 86-311-6265563, Fax: 86-311-6047450, E-mail: hanmei@hebmu.edu.cn