Vol.26 No.6（2004 December）：551-554

Poly(ADP-ribose) Polymerase Family

Jian Tang, Qi-Fu Li*

（Institute of Cell Biology, School of Life Sciences, Xiamen University,Xiamen 361005, China）

Abstract: It's an important field on separating and identifying functional nuclear matrix protein and nuclear matrix binding protein in research of the nuclear matrix nowadays. Through interacting with transcriptional factors, nuclear matrix binding elements and DNA, nuclear matrix binding protein plays a supporting and regulative role on DNA replication, transcription and modification. Poly(ADP-ribose) polymerase (PARP) is a kind of nuclear matrix binding protein of high conservation, and functions in areas such as repairing of genome damage, cell apoptosis, signal transduction, gene expression and regulation. Focus has been placed on its potential biological functions increasingly.

Key words: nuclear matrix; poly(ADP-ribose) polymerase; base excision repair

*Corresponding author. Tel: 86-592-2185363, Fax: 86-592-2181015, E-mail: chifulee@163.net