Vol.26 No.5（2004 October）：483-486

The Roles of HSP70 and gp96 in Viral Infection

Liu-Meng Yang¹, Hong-Liang Liu^1,2, Yong-Tang Zheng^1*

（¹Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; ²Graduate School of Chinese Academy of Science, Beijing 100039, China）

Abstract: Heat shock proteins (HSP), a large protein family, are part of extraordinarily conserved during evolution and play diverse roles in cellular functions. HSPs are expressed in cells in response to a range of stimuli, including heat, mitogen and microbial/viral infection. HSP binding to viral antigen complex can enhance the antiviral immune. The review briefly introduces the roles of HSP70 and gp96 in the viral infection.

Key words: HSP70; gp96; viral infection; HIV

*Corresponding author. Tel: 86-871-5195684, Fax: 86-871-5195684, E-mail: zhengyt@mail.kiz.ac.cn