Vol.26 No.4（2004 August）：377-380

The Function of Heterogeneous Nuclear Ribonucleoproteins in pre-mRNA Processing

Jia Huang, Xian-Hua Chen, Ping Xu*

（Laboratory of Genomic Phyisology and Brain Research Center, Fudan University, Shanghai 200433, China）

Abstract: Heterogeneous nuclear ribonucleoprotein (hnRNP) is a family of proteins that are highly expressed in eukaryotic cells and diffusely distributed in the nucleus. Various hnRNP proteins share similar structural characteristics and play a variety of functions in regulation of gene expression, including transcription, pre-mRNA splicing, mRNA export and mRNA decay. In this review, we briefly summarize the recent progresses regarding the function of hnRNP in pre-mRNA processing.

Key words: hnRNP; pre-mRNA processing; RNA-binding protein

*Corresponding author. Tel/Fax: 86-21-65642903, E-mail: matibuck@hotmail.com