Vol.26 No.3£¨2004 June£©£º271-275 Structure and Function of Eukaryotic DNA Polymerase ¦Ä ZHANG Hai Jiang, HAN Shi Wei, SANG Jian Li* £¨Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China£© Abstract: DNA polymerase ¦Ä (Pol¦Ä) is the core enzyme involved in the replication of DNA in eukaryote cell, and participates in several DNA repair pathways at the time. Pol¦Ä is a complex which is consist of several subunits. It has been now purified from mammalian, Schizosaccharomyces prombe and Saccharomyces cerevisiae and their composition of subunits were analyzed. But it is not known clearly. The general functions of Pol¦Ä are recognized now. Pol¦Ä plays a role in the replication of the whole leading strand, and it is required for the completion of Okazaki fragment synthesis. Otherwise Pol¦Ä is also involved in DNA repair. This function of DNA repair can reduce the mutation of DNA, however, the mechanism is not clear now. In the control of Pol¦Ä activation the researchers focus on the regulation of several protein factors on the activation of Pol¦Ä and regulation of transcription factors on the expression of the catalytic subunit. Key words: DNA polymerase ¦Ä; DNA replication; DNA repair; regulation *Corresponding author, E-mail: sangjianli@263.net |