Vol.26 No.1（2004 February）：19-25

Diploid-tetraploid Chimera Mouse and Its Applications in the Study of Gene Function

ZHOU Ru Jiang^1,2, CHEN Jian Quan¹, CHENG Guo Xiang¹*, HU Yi Ping²

（¹Shanghai Transgenic Research Center, Shanghai 201203, China; ²Research and Teaching Institute of Cell Biology, Department of Basic Medicines, Second Military Medical University, Shanghai 200433, China）

Abstract: As a specific type of rescuing chimerism, diploid-tetraploid aggregation approach usually results in pure animals derived predomintly from diploid component, which fulfills its wide application in gene expression and control research. This review hereby summerizes current diploid-tetraploid research progresses and its possible applications in gene function, meanwhile, the relevant prospective has also been envisaged objectively.

Key words: diploid-tetraploid chimera mouse; gene function

*Corresponding author, E-mail: chenggx@cngeneon.com