Vol.26 No.2£¨2004 April£©£º119-124 Advancement in Estrogen and Estrogen Receptor Signaling TAN Yin Fei, WANG Yan Ling* £¨State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China£© Abstract: The classical signaling pathway of estrogen receptor (ER) is the ligand-dependent one which involves ER¦Á and ER¦Â that belong to the classical nuclear steroid/thyroid receptor superfamily. Recent studies demonstrate that ER can also be activated through the crosstalk with other signaling pathways in estrogen-dependent or -independent manners. In addition, ER is involved in the regulation of cell proliferation by multiple interactions with other transcriptional factors to modulate their transcriptional activation. Furthermore, a cell surface form of ER can mediate rapid response of vascular endothelial cell to estrogen. Key words: estrogen; ER¦Á; ER¦Â; signaling pathway *Corresponding author, E-mail: wangyl@pangda.ioz.ac.cn |