Vol 35, No. 3 (3, 2013): 262-272

 

Long Noncoding RNAs: Regulatory Molecules in Mammalian Cells

 

Xiang Jianfeng, Yin Qingfei, Chen Lingling*

 

(State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

 

Abstract  It has become apparent that a number of organisms express abundant amounts of long noncoding RNAs (lncRNAs) that lack open reading frames. Rather than accumulating silently in the cell, recent research has shed new light onto the biological significance of lncRNAs. Here, we highlight some recent advances in our understanding of their important roles in nuclear architectures and in regulation of gene expression in mammalian cells.

 

Key words  long noncoding RNA; gene expression regulation; nuclear architecture; sno-lncRNAs

 
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No.XDA01010206) and the National Natural Science Foundation of China (Grant No.31271376)
 

*Corresponding author. Tel: +86-21-54921021, E-mail: linglingchen@sibcb.ac.cn

 
Browse:1724
您是第 位访问者,欢迎!
Sponsored by: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS  Chinese Society for Cell Biology
Address: Room 408, Building 31B, 319 Yue-Yang Road, Shanghai 200031, China  Tel: 86-21-54920950/2892/2895  Email: cjcb@sibs.ac.cn
沪ICP备05017545号