Vol 41,Issue 3(March 2019): 523-531


Advances of Biological Function and Mechanisms of SETDB1 in the Disease Pathogenesis


Tu Yuqing, Zhu Chennianci, Chen Jiaming, Wu Junwei, Ou Wen-Bin*


(Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Zhejiang Sci-Tech University, Hangzhou 310018, China)


Abstract  The histone methyltransferase family is the crucial participant in epigenetic regulation. SET domain bifurcated 1 (SETDB1), a member of the histone methyltransferase family, methylates lysine 9 position on histone H3 and shows multiply function in biological networks involving in transcriptional inhibition and autosomal gene silencing. This review summarizes the structure and function of SETDB1, the latest advances in the molecular mechanisms involved in the development and progression of related diseases, which highlight novel strategies for theoretical guidance and clinical treatment.


Keyword:  SETDB1; histone methyltransferase; multiply function; pathogenesis

Received: 2018-9-29  Accepted: 2018-11-3
This work was supported by the National Natural Science Foundation of China (Grant No.81728012), the Natural Science Foundation of Zhejiang Province (Grant No.LY18H160065), Science Foundation of Zhejiang Sci-Tech University (Grant No.14042107-Y), Nationa

*Corresponding author。Tel: +86-573-82586633, E-mail: ouwenbin@tsinghua.org.cn

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