Vol 41,Issue 3(March 2019): 352-362

 

The Research Progress of Primary Cilia

 

Zhang Donghui1, Huang Ning1, Chen Jianguo1,2, Teng Junlin1*

 

(1Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China; 2Center for Quantitative Biology, Peking University, Beijing 100871, China)

 

Abstract  The primary cilia, centrosome-based, specialized organelles that protrude from the cell membrane of most types of quiescent and differentiated mammalian cells. Primary cilia integrate multiple signals into specific outputs, therefore, defects of primary cilia can lead to a series of human diseases called ciliopathies. Here, we review the latest advances on primary cilia structure, ciliogenesis and disassembly process, and ciliary protein degradation pathway, and discuss the relationship between defects of primary cilia and ciliopathy, providing some cues for the diagnosis and treatment of ciliopathy.

 

Keyword:  primary cilia; ciliogenesis; primary cilia disassembly; ciliopathy

 
This work was supported by the National Natural Science Foundation of China (Grant No.31571376, 31630092)
 

*Corresponding author。 Tel: +86-10-62767044, E-mail: junlinteng@pku.edu.cn

 
 
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