Vol 41,Issue 3(March 2019): 342-351


Advances in Centrosome Assembly


Xia Yuqing1, Wang Tianning1, Teng Junlin1, Chen Jianguo1,2*


(1Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China; 2Center for Quantitative Biology, Peking University, Beijing 100871, China)


Abstract  In animal cells, centrosome is the major microtubule organizing center (MTOC), which plays important role in cell motility and polarity, cilia biogenesis and cytokinesis. Here we summarize the centrosome structure, centrosome duplication process, and recent adavances in the assembly of centrosome key components, which may provide some cues in further study of centrosome assembly and the underlying regulation mechanism.


Keyword:  centrosome; centrosome assembly; cartwheel structure; distal appendages; subdistal appendages

This work was supported by the National Natural Science Foundation of China (Grant No.31830110, 31630092)

*Corresponding author。Tel: 010-62755786, E-mail: chenjg@pku.edu.cn

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