Vol 41,Issue 3(March 2019): 333-341


Regulation of Microtubule Dynamics and Functions by Post-Translational Modifications and Microtubule-Binding Proteins


Xie Songbo1*, Zhou Jun1,2*


(1College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, China; 2College of Life Sciences, Nankai University, Tianjin 300071, China)


Abstract  Microtubules are highly dynamic cellular structures, and the dynamic property of microtubules is essential for various cellular activities. Microtubule-binding proteins play important roles in regulating microtubule dynamics and microtubule-mediated cell activities. The interaction of microtubule-binding proteins with microtubules is regulated by post-translational modifications of tubulin. In this review, we discuss how tubulin post-translational modifications and microtubule-binding proteins affect microtubule dynamics and microtubule-mediated cellular activities.


Keyword:   microtubule; microtubule dynamics; microtubule-binding protein; tubulin; post-translational modification; cellular activity

This work was supported by the National Natural Science Foundation of China (Grant No.31701216), Natural Science Foundation of Shandong Province (Grant No.ZR2017MC008) and China Postdoctoral Science Foundation (Grant No.2016M600553)

*Corresponding author。Tel: +86-531-86182518, E-mail: xiesongbo@sdnu.edu.cn; junzhou@sdnu.edu.cn

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