Vol 41,Issue 3(March 2019): 322-332


Tubulin Isotype and Its Function


Diao Lei1, Liu Mingyi2, Bao Lan1,2*


(1State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; 2School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China)


Abstract  Microtubules are the main cytoskeleton in almost all eukaryotic cells and composed of α/β tubulin. They play critical roles in various cellular processes. The functions of microtubules are regulated by microtubule- interacting proteins, tubulin post-translational modifications and tubulin isotypes. Previous studies have reported several isotypes of α/β-tubulin. The expression patterns of tubulin isotypes vary widely among different tissues and during development stages. Mutations in a variety of tubulin isotypes are able to cause nervous system diseases. Here, we review the research progress on tubulin isotypes, especially their roles in the regulation of microtubule function, the development of nervous system and related diseases.


Keyword:  microtubule; tubulin isotype; microtubule dynamics; neuron

This work was supported by the National Natural Science Foundation of China (Grant No.31330046) and Strategic Priority Research Program of Chinese Academy of Sciences (Grant No.XDB19000000)

*Corresponding author。Tel: +86-21-54921369, E-mail: baolan@sibcb.ac.cn

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